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ea0099p155 | Thyroid | ECE2024

Low TPO-antibody titers appear to promote aggressive thyroid cancers tumorigenesis: analysis of a large multinational dataset

Paparodis Rodis , Karvounis Evaggelos , Kapezanou Aikaterini , Bantouna Dimitra , Livadas Sarantis , Simeakis George , Askitis Dimitrios , Androulakis Ioannis , Angelopoulos Nicholas , Zianni Dimitra , Perogamvros Ilias , Boniakos Anastasios , Rizoulis Andreas , Imam Shanawaz , Carlos Jaume Juan

Introduction: In the thyroid gland, humoral immunity manifests with thyroid peroxidase (TPO) antibodies. In our studies, when TPO concentrations increased, thyroid cancers of follicular origin (TCFO) tended to develop less frequently.1 Other studies, though, reported an opposite trend in less aggressive cancers. The present work was designed to characterize the differential role of TPO antibodies in aggressive forms of TCFO (AGG) as compared to non-aggressive (NAG) ...
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Published by BioScientifica

Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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